Medical Voodoo. THEY CALL IT "CANCER"

THEY CALL IT "CANCER"

Researchers in Finland have discovered a drug combination that collaborates with the cancer cells' own MYC oncoprotein, which in large quantities causes self-destruction of the cancer cells.

When this combination is enhanced with immune system-boosting anti-PD-1 therapy, a more effective and long-lasting therapeutic effect can be seen in mice. These findings pave the way for new treatment combination strategies to harness the body’s natural defenses to fight "cancer".

JUHA KLEFSTRÖM AND HEIDI HAIKALA(PHOTO: VEIKKO SOMERPURO)

MYC, a gene with high cancer-initiating potential, is overexpressed in over 40% of breast cancers. While MYC programs breast cancer cells to build more macromolecules (anabolic metabolism) it also creates a metabolic vulnerability by making them more sensitive to a type of cell death known as apoptosis. Research Director Juha Klefstrom, PhD, University of Helsinki, Finland, has worked for a long time to exploit this apoptosis-sensitizing effect of MYC in the battle against the cancer.

Klefstrom and his research group found that, because of this vulnerability, cancer cells can be attacked with a "drug cocktail" that includes the diabetes drug metformin and venetoclax, a BCL-2 protein inhibitor that can induce apoptosis in cancer cells. The group identified metformin in a search for drugs that could boost the apoptosis-inducing action of venetoclax. Venetoclax has been approved to treat certain leukemias but not yet for the treatment of breast cancer.

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Cancer tumor is always white, not green, blue or red

Invasive Breast Carcinoma (IBC)Images of invasive breast cancer:

Left: Pathology slide image of cancerous breast tissue, Right: Tumor (white area) in fatty breast tissue.

Images courtesy: C. Whitaker Sewell, MD - Professor of Pathology, Emory University School of Medicine. https://www.cancerquest.org/patients/cancer-type/breast-cancer_
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Carcinoma of the breast is the most common cancer in the Western world and accounts for 20% of all cancers in women in the UK, with 1 in 10 women developing breast cancer in their lifetime (the prevalence of the condition in males is significantly less).By TeachMeSeries Ltd (2019)

Invasive carcinoma of the breast can beclassified into:

• Invasive ductal carcinoma (75-85%)
• Invasive lobular carcinoma (10%)
• Other subtypes (5%), such as medullary carcinoma or colloid carcinoma

Historically, ductal and lobular carcinomas were originally divided on the basis that ductal carcinomas arise in the ducts and lobular carcinomas arise in the lobules; it is now known that almost all breast carcinomas actually arise in the terminal duct lobular unit but this classification remains in use due to the different behaviour of the two subtypes.

http://teachmesurgery.com/breast/malignant-disease/invasive-breast-cancer/

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“This drug combo exploits specific metabolic vulnerabilities that high levels of MYC creates in tumor cells. Metformin and venetoclax, when given together, killed breast tumor cells in culture and blocked tumor growth in breast cancer animal models. Furthermore, the drugs efficiently killed authentic breast cancer tissue donated by breast cancer patients. The breast cancer samples were obtained fresh from surgeries performed in Helsinki University Hospital”, Dr. Klefstrom says.

However, the researchers soon discovered that the metformin plus venetoclax treatment only held tumors in check as long as the mice with implanted breast tumors were actively being treated with the drugs; once the treatment was stopped, the tumors grew back. The study shows that tumors were initially filled with tumor-killing lymphocytes; however, after the treatment they largely vanished and the remaining killer cells expressed PD-1, a marker of immune cell exhaustion.

To help the immune cells better fight the tumor, the researchers developed a new treatment strategy. First, they hit breast tumors with apoptosis-inducing drugs metformin and venetoclax to reduce the tumor size and to wake up killer lymphocytes. After the primary tumors were surgically removed, the mice were then treated with a triple combination: metformin, venetoclax and a PD-1-targeted antibody, which is used in immunotherapies to keep killer cells active long-term.

“With this combination the survival of mice carrying implanted tumors was extended dramatically in comparison to mice that were treated with only single or double combinations”, Klefstrom states.

Klefstrom highlights that this is a wonderful example of a translational study fundamentally aimed at taking research from bench to bedside. The key people from the University of Helsinki and Helsinki University Hospital (HUS) - basic researchers, pathologists, surgeons and oncologists - were all involved at the earliest stages of the study.

The first author of the study Dr Heidi Haikala notes: “It’s quite amazing how we’ve been able to bring a discovery from the lab bench all the way to the doors of the cancer clinics within the time frame of one PhD project. We are very excited about our findings and hope that they will translate to benefit breast cancer patients.”

“This is a great example of how scientists in academia, leveraging highly specialized tumor models and applying their unique insights, can contribute to the discovery of potential new treatments for people with cancer. It is also a testament to the great research being done in smaller countries like Finland,” states Joel Leverson, Ph.D., a Senior Scientific Director at AbbVie and one of the senior authors in the study.

“We finally have a drug combination that efficiently exploits MYC's apoptotic function and most importantly, these drugs can be tested in the clinic in real patients. We are currently working hard towards this next step," Klefstrom concludes.

Further information:

Research Director Juha Klefstrom, PhD, University of Helsinki

Email: juha.klefstrom@helsinki.fi

Klefström Lab

The collaborative study involved Juha Klefstrom, Satu Mustjoki and Timo Otonkoski groups at the University of Helsinki, FIMM, HUSLAB pathology, Helsinki University Hospital/HUS breast cancer surgery unit and HUS Comprehensive Cancer Center. Other key collaborators included University of Wurzburg, Germany, Oncotest GmbH (now part of Charles River Laboratories Inc.) and AbbVie, North Chicago. 

Reference: Heidi M. Haikala, Johanna M. Anttila, Elsa Marques, Tiina Raatikainen, Mette Ilander, Henna Hakanen, Hanna Ala-Hongisto, Mariel Savelius, Diego Balboa, Bjoern Von Eyss, Vilja Eskelinen, Pauliina Munne, Anni I. Nieminen, Timo Otonkoski, Julia Schüler, Teemu D. Laajala, Tero Aittokallio, Harri Sihto, Johanna Mattson, Päivi Heikkilä, Marjut Leidenius, Heikki Joensuu, Satu Mustjoki, Panu Kovanen, Martin Eilers, Joel D. Leverson, Juha Klefström. Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD1 immunotherapy. Nature Communications. DOI 10.1038/s41467-019-08541-2

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Sugar - cause of Candida - Candida cause of Cancer - This video saved my Life

Click for video

Explanation... Origin of your problems

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Candidiasis is a very common infection caused by the Candida fungus,
and can affect your skin, nails, organs, genitals, throat, bloodstream and mouth.
This infection can affect both men and women, but it's more commonly found in women.

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If you need help breaking free from sugar, keep reading!

By Vani Hari, New York Times Best Selling Author and Healthy Food Activist

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Sugar is toxic. Plain and simple.

It wreaks havoc on our bodies. Makes us age faster than we should. Destroys our skin. Makes it easy to carry a spare tire around our bellies and taxes our organs.

Pretty much everyone can agree that processed food and sugar are diet killers, and do nothing good for the body. Yet, sugar seems to control our lives and many of us struggle with uncontrollable cravings and mood swings that make it seem impossible to stop.

When you eat sugar, you light up the reward center in your brain that makes you feel euphoric - it's like being on a drug! But it quickly wears off and your brain wants more of that feeling and tells you to eat more sugar... This is a cycle that is really hard to stop.

I sat down with my team and we brainstormed how to solve this issue once and for all. We spent months creating something amazing that I know you are going to want to be a part of... a groundbreaking 7-Day Sugar Detox Program to finally rid your diet of refined sugar that won't leave you feeling deprived.

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I read your emails every day and listen to the problems you're having trying to eliminate processed food from your life - and the NUMBER ONE issue you've expressed to me is your struggle to tame cravings and avoid SUGAR... .

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I have been in your shoes. I know the pain and struggle that you are going through is heartbreaking because I've been there.

I'm human, just like you, and I love sweets! For most of my life, I was addicted to sugar. As a result, my health suffered a lot too. My teeth were awful, my skin was a mess, my body was inflamed, my energy was low and I was overweight. I never want to feel that way again and I know from personal experience how changing your diet can transform your life. Let me help you too!

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"My sugar intake was out of control! My worst time of day was from 8PM to 10PM, when I couldn't inhale enough cookies and/or dark chocolate truffles and/or ice cream. Every night I had to have something sweet. Then when I saw the Food Babe's message about the Sugar Detox, I knew that it was time to make another healthy change to my diet. The best part was getting on the scale and finding that I had lost 4 pounds! I am extremely motivated now, and even started to exercise. All in all, I am trying to maintain a healthy lifestyle and have confidence that I'll be able to continue to eat good foods! Thank you!!" -Lesli

"I completed the 7 day detox with my husband, lost 2 pounds and started taking morning walks. I feel much more energized and focused. I started out with the vegetarian menu but added some of the meat recipes in to encourage my husband to continue. All the recipes were good and filling. I did not feel hungry. My husband was able to take leftovers to work each day because the portions were large enough. Following the detox, I am focused on eating more fresh vegetables and fruits, and continuing to make variations of the recipes provided for the detox. I love the sunny scramble and the coconut chia pudding! I'm also shopping more at the local farmers market. Note that it is helpful to have a blender and food processor in advance of the detox to assist with prep. Thanks Food Babe team for the encouragement and easy to follow instructions. I recommend that everyone try this detox!" -Sheila

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"I am a firefighter. Between my schedule and sleep habits I've been in a rut for a long time with choosing convenience over quality. I also have a horrible sweet tooth. One that causes me to have regular binges on the worst of the worst types of candy. My wife has been trying to get me to reduce my sugar intake, but it has had such a hold on me for so long; I didn't know where to start. I'm happy to say, I just completed the 7 day sugar detox. It was a great experience! The biggest difference was the food. I was surprised at how much I enjoyed it all. The other thing that was noteworthy was, upon completion, I didn't have much of a desire for sugar. At least not in mass quantities. I am only a have few days removed from it, but I still desire to eat healthy. My wife has been a huge help. She prepared everything and all I had to do was show up to the table and eat. And for that, I am exceedingly grateful.I think my relationship with food is taking a much needed positive turn. For me it is less about the weight loss and more about good health for me and my family. Thank you food babe! (I lost 14 lbs and I feel great)." -Matt

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"My husband and I have finished the sugar detox on Monday 03/21/2016! I thought it would be impossible but it wasn't and we succeeded! The first 3 days were hard for myself and after that it was just a part of the routine. Don't get me wrong, yes I wanted a cheeseburger but it wasn't a must have at the time. My husband really struggled on the last day, probably because he knew he could have pasta the next day. I lost 5 lbs through the detox and i didn't workout through the detox because I didn't have that many carbs in my body besides the carbs from the vegetables. We feel so much better after doing the detox and now know that we have self control and that sugar does not run our lives. Thank you for the push with the 7- day sugar detox, it was worth the money! Keep encouraging others to be healthy, you are doing a great thing in our communities! Organic and Non GMO is the way to go!" -Lia

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https://foodbabe.com/sugardetox/