3.91Graviola seems to be stronger in killing colon cancer cells than Adriamycin
Graviola seems to be stronger in killing colon cancer cells than Adriamycin
Overview and Applications
Soursop or Graviola is native to the Amazon rainforest; a small tree growing up to 15 feet (5 meters) tall; it is much sought after for its delicious fruit.
However, Graviola bark, leaves, root, and fruits have also been used as traditional remedies in South America for many centuries.
There is ongoing cancer-research on this plant concerning the specific phytochemicals (Annonaceous acetogenins) that are demonstrating the strongest anticancer and antiviral properties.
Extracts have been shown to have antiviral, antiparasitic, antirheumatic, astringent, emetic, antileishmanial and cytotoxic effects. Graviola has also been shown to be effective against multi-drug resistant cancer cell lines.
Graviola seems to effectively target and kills malignant cells in more than 10 different types of cancer, including colon, breast, prostate, lung, and pancreatic cancer.
It is believed to be far stronger in killing colon cancer cells than Adriamycin® (Doxorubicin hydrochloride), a chemotherapy given as treatment for certain types of cancer. It may be a natural alternative as such for traditional cancer treatments.
Graviola hunts down selectively - and kills cancer cells without harming healthy cells; unlike chemotherapy that indiscriminately seeks and destroys all actively reproducing cells - (even normal, healthy ones).
Research on this plant has focused on its anti-cancerous effect but the plant has been used for a long time in traditional medicine in Surinam to treat a number of ailments, such as:
hypertension, ringworm, influenza, scurvy, rashes, malaria, neuralgia, dysentery, arthritis, palpitations, rheumatism, nervousness, high blood pressure, insomnia, diarrhea, fever, nausea, boils, dyspepsia, and muscle spasm.
General uses are: cancer treatment, herpes, infections, parasitic infections and sedation.
Phytochemicals
There are many constituents in Graviola (Soursop).Acetogenins, quinolines, isoquinolines, annopentocins and annomuricins, Coreximine, reticuline subfractions.
Acetaldehyde, Amyl-caproate, Amyloid, Annonain, Anomuricine, Anomuricinine, Anomurine, Anonol, Atherosperminine, Beta-sitosterol, Campesterol, Cellobiose, Citric-acid, Citrulline, Coclaurine, Coreximine, Dextrose, Ethanol, Folacin, Fructose, Gaba, Galactomannan, Geranyl-caproate Glucose, HCN, Isocitric-acid, Lignoceric-acid, Malic-acid, Manganese, Mericyl-alcohol, Methanol, Methyl-hex-2-enoate, Methyl-hexanoate, Muricine, Muricinine, Muricapentocin, Muricoreacin, Myristic-acid, P-coumaric-acid, Paraffin, Potassium-chloride, Procyanidin, Reticuline, Scyllitol, Stearic-acid, Stepharine, Stigmasterol, Sucrose, Tannin, Xylosyl-cellulose.
Pharmacology
Methanolic extract of Annona muricata (Annonaceae) seeds was tested for antiparasitic activity against E. histolytica, N. brasiliensis, M. dessetae and A. salina.
The acetogenins (natural chemicals) are found to be responsible for that important activity.
In a plant screening program by the National Cancer Institute, (MSKCC, NCI +++), the leaves and stem of Graviola showed active cytotoxicity against cancer cells.
Focus of the research was on a novel set of phytochemicals (annonaceous acetogenins).
The Annonaceous acetogenins are only found in the Annonaceae family.
Fractionation of the leaves resulted in the isolation of two new Annonaceous acetogenins, muricoreacin and murihexocin C. These compounds showed significant cytotoxicities among six human tumor cell lines with selectivities to the prostate adenocarinoma (PC-3) and pancreatic carcinoma (PACA-2) cell lines.
The antitumor, properties of these annonaceous acetogenins have been reported.
Researchers reported that the Annonaceous acetogenin, bullatacin, preferentially killed multi-drug resistant cancer cells because it blocked production of adenosine triphosphate, ATP (the chief energy-carrying compound).
However the Annonaceous acetogenins also appear in other species from this family such as Annona Montana.
Over 350 of these acetogenins have been isolated from 37 species.
Some of the Annonaceous acetogenins are not only effective in killing tumors that have proven resistant to anti- cancer agents, but also seem to have a special affinity for such resistant cells.
Surviving cancer cells from chemotherapy may develop resistance to the agent originally used against them as well as to other, even unrelated, drugs (f. ex. PANCREATIC multi-drug resistance, MDR).
The fruit and the leaves of Annona muricata are used in traditional medicine for their tranquillizing and sedative properties.
Extracts of the plant have been shown results that imply that the fruit possesses anti-depressive effects, possibly induced by three alkaloids, annonaine (1), nomuciferine (2) and asimilobine (3), isolated from the fruit.
Fractionation of the leaves resulted in the isolation of annopentocins A B and C and cis- and trans-annomuricin-D-ones.
Compound 1 was selectively cytotoxic to pancreatic carcinoma cells (PACA-2), and 2 and 3 were selectively cytotoxic to lung carcinoma cells (A-549);
the mixture of 4 and 5 was selectively cytotoxic for the lung (A-549), colon (HT-29), and pancreatic (PACA-2) cell lines with potencies equal to or exceeding those of Adriamycin.
One of the documented mechanisms of action of Graviola is by decreasing energy to abnormal cells (ATP-inhibitor).
Taking supplements that increase cellular energy, such as CoQ10, will counteract or disable this one mechanism of action of Graviola.
_
tropilab.com
References
Titre du document / Document title
Isoquinoline derivatives isolated from the fruit of Annona muricata as 5-HTergic 5-HT[1A] receptor agonists in rats : Unexploited antidepressive (lead) products.
Auteur(s) / Author(s)
HASRAT J. A.(¹); DE BRUYNE T.(¹); DE BACKER J.-P.(²); VAUQUELIN G.(²); VLIETINCK A.(¹)
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(¹) Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, 2610, Antwerp, BELGIQUE.
(²) Department of Protein Chemistry, Free University of Brussels, Paardenstraat 65, 1640, St Genesius Rode, BELGIQUE.
Two New Mono-Tetrahydrofuran Ring Acetogenins, Annomuricin E and Muricapentocin, from the Leaves of Annona muricata.
Geum-soog Kim, +§Lu Zeng, +Feras Alali, +Lingling L. Rogers, +Feng-E. Wu, +Jerry L. McLaughlin,*+ and Soelaksono Sastrodihardjo±
Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana 47907, and Department of Education and Culture, Center of Interuniversities, Biology Division, Bandung Institute of Technology, 10 Yanesba St., Bandung 40132, Indonesia Received November 26, 1997.
Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana 47907, and Department of Education and Culture, Center of Interuniversities, Biology Division, Bandung Institute of Technology, 10 Yanesba St., Bandung 40132, Indonesia Received November 26, 1997.
Annona muricata L. USDA, NRCS. 2008. The PLANTS Database http://plants.usda.gov/ , Nov, 2008). National Plant Data Center , Baton Rouge, LA 70874-4490 USA.
Wu FE, Zeng L, Gu ZM, et al. Muricatocins A and B, two new bioactive monotetrahydrofuran Annonaceous acetogenins from the leaves of Annona muricata. J Nat Prod. 1995;58(6):902-908.
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torstai 28. elokuuta 2014
CANCER PATIENT´s SURVIVAL DIET
LATEST CANCER INFORMATION | from Johns Hopkins | Graviola.fi
AFTER YEARS OF TELLING PEOPLE CHEMOTHERAPY IS THE ONLY WAY TO TRY AND ELIMINATE CANCER, JOHNS HOPKINS IS FINALLY STARTING TO TELL YOU THERE IS AN ALTERNATIVE WAY …
AFTER YEARS OF TELLING PEOPLE CHEMOTHERAPY IS THE ONLY WAY TO TRY AND ELIMINATE CANCER, JOHNS HOPKINS IS FINALLY STARTING TO TELL YOU THERE IS AN ALTERNATIVE WAY …
1. Every person has cancer cells in the body. These cancer cells do not show up in the standard tests until they have multiplied to a few billion. When doctors tell cancer patients that there are no more cancer cells in their bodies after treatment, it just means the tests are unable to detect the cancer cells because they have not reached the detectable size.
2. Cancer cells occur between 6 to more than 10 times in a person's lifetime.
3. When the person's immune system is strong the cancer cells will be destroyed and prevented from multiplying and forming tumors.
4. When a person has cancer it indicates the person has multiple nutritional deficiencies. These could be due to genetic, environmental, food and lifestyle factors.
5. To overcome the multiple nutritional deficiencies, changing diet and including supplements will strengthen the immune system.
6. Chemotherapy involves poisoning the rapidly-growing cancer cells and also destroys rapidly-growing healthy cells in the bone marrow, gastro-intestinal tract etc, and can cause organ damage, like liver, kidneys, heart, lungs etc.
7. Radiation while destroying cancer cells also burns, scars and damages healthy cells, tissues and organs.
8. Initial treatment with chemotherapy and radiation will often reduce tumor size. However prolonged use of chemotherapy and radiation do not result in more tumor destruction.
9. When the body has too much toxic burden from chemotherapy and radiation the immune system is either compromised or destroyed, hence the person can succumb to various kinds of infections and complications.
10. Chemotherapy and radiation can cause cancer cells to mutate and become resistant and difficult to destroy. Surgery can also cause cancer cells to spread to other sites.
11. An effective way to battle cancer is to STARVE the cancer cells by not feeding it with foods it needs to multiple.
What cancer cells feed on:
a. Sugar is a cancer-feeder. By cutting off sugar it cuts off one important food supply to the cancer cells. Note: Sugar substitutes like NutraSweet, Equal, Spoonful, etc are made with Aspartame and it is harmful. A better natural substitute would be Manuka honey or molasses but only in very small amounts. Table salt has a chemical added to make it white in colour. Better alternative is Bragg's aminos or sea salt.
b. Milk causes the body to produce mucus, especially in the gastro-intestinal tract. Cancer feeds on mucus. By cutting off milk and substituting with unsweetened soy milk, cancer cells will starved.
c. Cancer cells thrive in an acid environment. A meat-based diet is acidic and it is best to eat fish, and a little chicken rather than beef or pork. Meat also contains livestock antibiotics, growth hormones and parasites, which are all harmful, especially to people with cancer.
d. A diet made of 80% fresh vegetables and juice, whole grains, seeds, nuts and a little fruits help put the body into an alkaline environment. About 20% can be from cooked food including beans. Fresh vegetable juices provide live enzymes that are easily absorbed and reach down to cellular levels within 15 minutes t o nourish and enhance growth of healthy cells.
To obtain live enzymes for building healthy cells try and drink fresh vegetable juice (most vegetables including bean sprouts) and eat some raw vegetables 2 or 3 times a day. Enzymes are destroyed at temperatures of 104 degrees F (40 degrees C).
e. Avoid coffee, tea, and chocolate, which have high caffeine. Green tea is a better alternative and has cancer-fighting properties. Water--best to drink purified water, or filtered, to avoid known toxins and heavy metals in tap water. Distilled water is acidic, avoid it.
12. Meat protein is difficult to digest and requires a lot of digestive enzymes. Undigested meat remaining in the intestines will become putrified and leads to more toxic buildup.
13. Cancer cell walls have a tough protein covering. By refraining from or eating less meat it frees more enzymes to attack the protein walls of cancer cells and allows the body's killer cells to destroy the cancer cells.
14. Some supplements build up the immune system (IP6, Flor-ssence, Essiac, anti-oxidants, vitamins, minerals, EFAs etc.) to enable the body's own killer cells to destroy cancer cells. Other supplements like vitamin E are known to cause apoptosis, or programmed cell death, the body's normal method of disposing of damaged, unwanted, or unneeded cells.
15. Cancer is a disease of the mind, body, and spirit. A proactive and positive spirit will help the cancer warrior be a survivor.
Anger, unforgiving and bitterness put the body into a stressful and acidic environment. Learn to have a loving and forgiving spirit. Learn to relax and enjoy life.
16. Cancer cells cannot thrive in an oxygenated environment. Exercising daily, and deep breathing help to get more oxygen down to the cellular level. Oxygen therapy is another means employed to destroy cancer cells.
(PLEASE SHARE IT TO PEOPLE YOU CARE ABOUT) | Eating for Better Health
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perjantai 22. elokuuta 2014
Memorial Sloan Kettering Cancer Center - Graviola Clinical Summary
INTEGRATIVE MEDICINE Graviola
Clinical Summary
Graviola, a tree prevalent in the rain forests of Africa, South America, and Southeast Asia, has been used in traditional medicine in many countries.
Extracts of graviola show antiviral (1), antiparasitic, antirheumatic, astringent, emetic (2), antileishmanial and cytotoxic (3) (4), antinociceptive, anti-inflammatory (9), antihyperglycemic (10) and anticancer effects (5)(12) (13) in vitro and in vivo.
Extracts of graviola show antiviral (1), antiparasitic, antirheumatic, astringent, emetic (2), antileishmanial and cytotoxic (3) (4), antinociceptive, anti-inflammatory (9), antihyperglycemic (10) and anticancer effects (5)(12) (13) in vitro and in vivo.
Purported Uses
- Cancer treatment
- Herpes
- Infections
- Parasitic infections
- Sedation
Constituents
- Acetogenins
- Quinolines and isoquinolines
- Annopentocins
- Annomuricins
- Coreximine and reticuline
(6) (7)
Mechanism of Action
Annonaceous acetogenins, phytochemicals isolated from the leaves, bark and twigs of graviola, are thought to be the active ingredients.
The ethanolic extract of Annona muricata was found to inhibit the Herpes simplex virus (1) and effective against Leishmania braziliensis, L. panamensis promastigotes, and the cancer cell line U 937 (3) and hepatoma cell lines (8) in vitro.
The ethanolic extract of Annona muricata was found to inhibit the Herpes simplex virus (1) and effective against Leishmania braziliensis, L. panamensis promastigotes, and the cancer cell line U 937 (3) and hepatoma cell lines (8) in vitro.
Graviola extracts were shown to be lethal to the fresh-water mollusk Biomphalaria glabrata, which acts as a host for the parasitic worm, Schistosoma mansoni (2).
Alkaloids from graviola are detrimental to the survival of dopaminergic nerve cells in vitro. This may result in neuronal dysfunction and degeneration.
Graviola-induced cell death was inhibited by glucose supplementation suggesting that cell death may have been caused by energy depletion (6).
Graviola has also been shown to stimulate serotonine receptors (7).
Graviola extracts were effective against the growth of Adriamycin-resistant human mammary adenocarcinoma (MCF-7/Adr) by blocking access of cancer cells to ATP and by inhibiting the actions of plasma membrane glycoprotein (5).
Graviola-induced cell death was inhibited by glucose supplementation suggesting that cell death may have been caused by energy depletion (6).
Graviola has also been shown to stimulate serotonine receptors (7).
Graviola extracts were effective against the growth of Adriamycin-resistant human mammary adenocarcinoma (MCF-7/Adr) by blocking access of cancer cells to ATP and by inhibiting the actions of plasma membrane glycoprotein (5).
They also inhibited expression of HIF-1α, NF-κB, glucose transporters, and glycolytic enzymes resulting in decreased glucose uptake and ATP production in pancreatic cancer cells (12); and downregulated EGFR expression in another study (13).
_
____________
Graviola's purported anti-cancer potency comes largely from its ability to reduce the supply of adenosine triphosphate (ATP) to cancer cells.
ATP often provides metabolic energy to healthy cells as well, and some nutritional supplements, notably Coenzyme Q10, are known for increasing ATP. For this reason, CoQ10 may neutralize the effect of graviola and they should not be taken together [source: Taylor].
Some side effects follow from graviola's areas of bioactivity.ATP often provides metabolic energy to healthy cells as well, and some nutritional supplements, notably Coenzyme Q10, are known for increasing ATP. For this reason, CoQ10 may neutralize the effect of graviola and they should not be taken together [source: Taylor].
Studies on animal subjects have demonstrated that the plant can dilate blood vessels and lower blood pressure, so those whose blood pressure is already low, or are already on medication to reduce hypertension, should consult their physician before taking graviola [source: Wright]. Also, a large dose taken at one time can cause nausea and vomiting [source: Taylor].
Elektroninsiirtoketju
Elektroninsiirtoketju on mitokondrion sisäkalvolla (eukaryootit) tai solukalvon kalvoproteiineissa (bakteerit) tapahtuva energiaa tuottava reaktiosarja,jossa sitruunahappokierrossa ja sitä edeltäneissä reaktioissa koentsyymeille NADH ja FADH2 siirtyneitä elektroneja siirrellään elektroninsiirtoketjun entsyymiltä toiselle, jolloin elektronit menettävät potentiaalienergiaansa vähitellen, vapauttaen samalla energiaa.Vapautuvan energian avulla mitokondrion matriksista pumpataan protoneja mitokondrion kalvojen välitilaan, mikä aiheuttaa elektrokemiallisen gradientin eli potentiaali- ja protonikonsentraatioeron matriksin ja välitilan välille. Muodostunut gradientti purkautuu ATP-syntaasientsyymin kautta, jolloin muodostuu suurenergiaista fosfaattiyhdistettä, ATP:tä.
https://fi.wikipedia.org/wiki/Elektroninsiirtoketju
https://www.researchgate.net/figure/Electron-transfer-chain-in-the-inner-membrane-of-mitochondrion-The-electron-transfer_fig1_232699942
The Annonaceous acetogenins are promising new antitumor and pesticidal agents that are found only in the plant family Annonaceae.
Chemically, they are derivatives of long-chain fatty acids. Biologically, they exhibit their potent bioactivities through depletion of ATP levels via inhibiting complex I of mitochondria and inhibiting the NADH oxidase of plasma membranes of tumor cells. Thus, they thwart ATP-driven resistance mechanisms. This review presents the progress made in the chemistry, biology, and development of these compounds since December 1995
https://pubs.acs.org/doi/abs/10.1021/np980406d
The Annonaceous acetogenins are promising new antitumor and pesticidal agents that are found only in the plant family Annonaceae.
Chemically, they are derivatives of long-chain fatty acids. Biologically, they exhibit their potent bioactivities through depletion of ATP levels via inhibiting complex I of mitochondria and inhibiting the NADH oxidase of plasma membranes of tumor cells. Thus, they thwart ATP-driven resistance mechanisms. This review presents the progress made in the chemistry, biology, and development of these compounds since December 1995
https://pubs.acs.org/doi/abs/10.1021/np980406d
Understanding mitochondrial complex I assembly in health and disease
Complex I (NADH:ubiquinone oxidoreductase) is the largest multimeric enzyme complex of the mitochondrial respiratory chain, which is responsible for electron transport and the generation of a proton gradient across the mitochondrial inner membrane to drive ATP production. Eukaryotic complex I consists of 14 conserved subunits, which are homologous to the bacterial subunits, and more than 26 accessory subunits. In mammals, complex I consists of 45 subunits, which must be assembled correctly to form the properly functioning mature complex. Complex I dysfunction is the most common oxidative phosphorylation (OXPHOS) disorder in humans and defects in the complex I assembly process are often observed.
Researchers exploring the mechanisms that graviola uses claim that the acetogenins in the plant can distinguish cancerous cells from healthy cells because cancer cells have a consistently higher level of cellular activity.
The acetogenins recognize and selectively inhibit the cancer cells.
Pregnant women are advised to avoid graviola because the high energy in the cells of the developing fetus may trigger the botanical's toxic activity [source: Wright]. The plant was also found to stimulate the uterus in an animal study [source: Taylor].
The most detrimental effect attributed to graviola is that it "may cause neural dysfunction and degeneration leading to symptoms reminiscent of Parkinson's Disease" [source: Memorial Sloan-Kettering]. The first study to make this assertion was conducted by French researchers in Guadeloupe, who found an abnormally high presence of atypical Parkinson's amongst a poor population that used graviola for both food and medicine. However, the outbreak of neurological disorders was relatively confined, whereas the popularity of graviola is widespread in the region [source: Wright]. In her book "The Healing Power of Rainforest Herbs," botanist Leslie Taylor acknowledges that graviola seeds and roots contain alkaloids that have shown neurotoxic effects in tests. For this reason, she recommends using the leaves instead [source: Taylor].
________
Graviola -hedelmän ja -lehtien aineosat, annonaceus acetogenins, etsivät
nopeasti kasvavat, paljon energiaa tuhlaavat syöpäsolut ja estävät niiden ravinnon
ja hapen saannin.
- Graviolan aineosat pysäyttävät syöpäsolujen kasvun jo niiden energian-
tuotannossa, mitokondrioissa, Complex 1: n elektronisiirto -ketjussa.
Electron transport chain COMPLEX 1 (NADH ubiquinone oxidoreductase)
The Warburg hypothesis, sometimes known as the Warburg theory of cancer,
postulates that the driver of tumorigenesis is an insufficient cellular respiration caused by insult to mitochondria.[1] The term Warburg effect describes the observation that
cancer cells, and many cells grown in-vitro, exhibit glucose fermentation even when
enough oxygen is present to properly respire. In other words, instead of fully respiring
in the presence of adequate oxygen, cancer cells ferment.
He hypothesized that cancer, malignant growth, and tumor growth are caused by the
fact that tumor cells mainly generate energy (as e.g., adenosine triphosphate / ATP)
by non-oxidative breakdown of glucose (a process called glycolysis).
This is in contrast to "healthy" cells which mainly generate energy from oxidative
breakdown of pyruvate.
Pyruvate is an end-product of glycolysis, and is oxidized within the mitochondria.
4.2. Annonaceous Acetogenins
AGEs are a unique class of C-35/C37 secondary metabolites derived from long chain
(C-32/C34) fatty acids in the polyketide pathway. They are usually characterized by a combination of fatty acids with a 2-propanol unit at C-2 that forms a methyl-substituted α,β-unsaturated γ-lactone [72]. Since the discovery of uvaricin from Uvaria accuminata
in 1982, more than 500 AGEs have been identified from different parts of the plants in the Annonaceae family [73,74]. Due to the special structures and extensive biological activities, AGEs have attracted significant scientific interest in recent years.
Various biological activities have been reported for AGEs, including antimalarial, antiparasitic and pesticidal activities [72,75].
However, the biological activities of AGEs are primarily characterized with toxicity against cancer cells and inhibitory effects against the mitochondrial complex I (mitochondrial NADH: ubiquinone oxidoreductase) [76,77].
Phytochemical investigations and biological studies on different parts of the A. muricata plant resulted in the identification of a wide array of AGE compounds, as summarized in Table 1.
The chemical structures of the major acetogenins are shown inFigure 2.
To the best of our knowledge, at the time of preparation (January 2015) of the present review over 100 AGEs have been identified in A. muricata.
The Electron Transport Chain & complexes I-IV that pump protons out of the Mitochondria by the transfer of the electrons carried on NADH & FADH2 to maintain the concentration gradient of the protons "high in the intermembrane space & low in the matrix of the Mitochondria"
(Scientific Reports volume 6, Article number: 36462 (2016) doi:10.1038/srep36462)
In this study, we evaluated a novel PAI-1 inhibitor, annonacinone, a natural product from the Annonaceous acetogenins group
- High plasma levels of PAI-1 are related to the development of thrombosis as well as several other pathologies such as cardiovascular diseases and metabolic disturbances1,2,3.
- Moreover PAI-1 is able to promote tumor angiogenesis and high PAI-1 level in solid tumors are associated with a poor prognosis 4,5.
http://graviolateam.blogspot.com/2018/05/graviola-aka-soursop-what-you-need-to.html
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Graviolan hedelmiä, siemeniä, kuorta, lehtiä ja juurta on Keski- ja Etelä-Amerikan sekä Karibian kansojen keskuudessa jo vuosisatojen ajan käytetty myös perinteisinä luonnonrohtoina saatujen kokemusten ja monipuolisiksi havaittujen vaikutustensa vuoksi.
Paitsi hedelmiä, myös sen siemeniä, varsia ja lehtiä on perinteisesti käytetty kansanlääkinnässä mitä erilaisemmissa terveysongelmissa ja erilaisempiin tarkoituksiin. Parhaiten Graviolan käyttö tunnetaankin Etelä-Amerikassa, jossa sen kuoresta, juurista ja lehdistä on valmistettu teetä erilaisten vaivojen hoitoon.
Perun Andien alkuperäiskansojen tiedetään käyttävän graviolan lehtiteetä lisäämään limakalvojen liman eritystä ja rauhoittamaan niitä. Joissakin Perun osissa diabeetikot käyttävät sekä kuorta että lehtiä tasaamaan veren sokeria. Guyanassa lehtiteetä käytetään lähinnä elinvoimaa parantavana ja virkistävänä juomana, Braziliassa maksan toimintaa edistämään sekä Länsi-Intian saarilla puolestaan helpottamaan yskää ja avaamaan hengitystä.
Paitsi hedelmiä, myös sen siemeniä, varsia ja lehtiä on perinteisesti käytetty kansanlääkinnässä mitä erilaisemmissa terveysongelmissa ja erilaisempiin tarkoituksiin. Parhaiten Graviolan käyttö tunnetaankin Etelä-Amerikassa, jossa sen kuoresta, juurista ja lehdistä on valmistettu teetä erilaisten vaivojen hoitoon.
Perun Andien alkuperäiskansojen tiedetään käyttävän graviolan lehtiteetä lisäämään limakalvojen liman eritystä ja rauhoittamaan niitä. Joissakin Perun osissa diabeetikot käyttävät sekä kuorta että lehtiä tasaamaan veren sokeria. Guyanassa lehtiteetä käytetään lähinnä elinvoimaa parantavana ja virkistävänä juomana, Braziliassa maksan toimintaa edistämään sekä Länsi-Intian saarilla puolestaan helpottamaan yskää ja avaamaan hengitystä.
Nykyisin myös tutkijat ovat kiinnostuneet graviolan perinteisestä käytössä ja sen mahdollisista vaikutuksista jopa joidenkin vakavien sairauksen hoidossa.
Mm. New Yorkissa sijaitsevassa maailmankuulussa syöpätutkimuskeskuksessa Memorial Sloan-Kettering Centerissä tehdyissä tutkimuksissa on havainnut graviolalla olevan vaikutusta viruksiin, parasiitteihin sekä reumaan.
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http://graviola.fi/kauppa-uutuudet/graviola-tee-pulver/
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http://graviola.fi/kauppa-uutuudet/graviola-tee-pulver/
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.jpg)
Graviola -mehut
GRAVIOLA MEHU - Todella voimallinen juoma! - Info puh. 041-492 6015 -
Totuttele varovasti maistelemalla ja laimentamalla.
- Graviola -mehun vaikutus on välitön ja tehokas!
100% puhdasta mehua tuoreista ja kypsistä Graviola-hedelmistä Graviola –mehu on puhdasta, erittäin laadukasta Graviolan hedelmälihaa, johon ei ole lisätty vettä ja mehu onkin melko sakeaa.
Kypsät Graviola-hedelmät poimitaan käsin, kuoritaan ja niiden hedelmälihasta poistetaan siemenet. Tämän jälkeen hedelmäliha mehustetaan tynnyreissä ja jäädytetään välittömästi tuottajamme toimesta, jotta mehun laatu ja aineksien säilyvyys saadaan taattua. Pian tämän jälkeen mehu pastöroidaan ja pullotetaan laadun ja hyllyiän maksimoimiseksi.
Mehu on täysin säilöntä- ja torjunta-aineetonta. Jokainen hedelmätoimitus tarkistetaan torjunta-aineiden varalta ulkoistetussa, erikoistuneessa laboratoriossa.
Sisältö: Graviola (Annona muricata)
Suositeltu käyttö: n. 50-100ml päivittäin.
Herkullisen makunsa ansiosta Graviolalla on lukuisia käyttötapoja: virkistävän smoothien pohjana tai osana pirtelöä, siitä voi tehdä herkullista sorbettia tai jäätelöä tai vaikka käyttää osana aivan uutta cocktailia.
Aluksi on suositeltavaa sekoittaa mehu veteen tai toiseen tuoremehuun Graviolan vomakkuuden vuoksi.
Säilytä avattuna jääkaapissa ja nauti 5 päivän sisään kuten muutkin aidot tuoremehut.
Ravintoarvot 100g Energia 60 kcal Proteiini 1 g Hiilihydraatteja 15 g Rasvaa 0 g Kuituja 1 g C-vitamiinia 26 mg. Toimitus: Toimitusaika 8 vrk
Kypsät Graviola-hedelmät poimitaan käsin, kuoritaan ja niiden hedelmälihasta poistetaan siemenet. Tämän jälkeen hedelmäliha mehustetaan tynnyreissä ja jäädytetään välittömästi tuottajamme toimesta, jotta mehun laatu ja aineksien säilyvyys saadaan taattua. Pian tämän jälkeen mehu pastöroidaan ja pullotetaan laadun ja hyllyiän maksimoimiseksi.
Mehu on täysin säilöntä- ja torjunta-aineetonta. Jokainen hedelmätoimitus tarkistetaan torjunta-aineiden varalta ulkoistetussa, erikoistuneessa laboratoriossa.
Sisältö: Graviola (Annona muricata)
Suositeltu käyttö: n. 50-100ml päivittäin.
Herkullisen makunsa ansiosta Graviolalla on lukuisia käyttötapoja: virkistävän smoothien pohjana tai osana pirtelöä, siitä voi tehdä herkullista sorbettia tai jäätelöä tai vaikka käyttää osana aivan uutta cocktailia.
Aluksi on suositeltavaa sekoittaa mehu veteen tai toiseen tuoremehuun Graviolan vomakkuuden vuoksi.
Säilytä avattuna jääkaapissa ja nauti 5 päivän sisään kuten muutkin aidot tuoremehut.
Ravintoarvot 100g Energia 60 kcal Proteiini 1 g Hiilihydraatteja 15 g Rasvaa 0 g Kuituja 1 g C-vitamiinia 26 mg. Toimitus: Toimitusaika 8 vrk
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