lauantai 21. maaliskuuta 2020

Studies Claim Malaria Drug Chloroquine Effective Against Coronavirus

  • Chloroquine phosphate, an old-fashioned anti-malarial drug, has shown strong results against COVID-19 infections.
  • According to South Korean and China human treatment guidelines, chloroquine is effective in treating COVID-19.
  • Zinc appears to be the most effective agent in disrupting the virus and preventing the ‘cytokine storm’
  • In the 2019–20 coronavirus pandemic, a number of deaths due to COVID-19 have been attributable to cytokine release storms.



Studies Claim Malaria Drug Chloroquine Effective Against Coronavirus






JAMES DELINGPOLE


Sure this Coronavirus pandemic is a misery but I’m much 
more optimistic than most at the moment. Here’s one of the reasons: there’s an effective treatment already and it’s available and cheap, according to studies.
Chloroquine phosphate, an old-fashioned anti-malarial drug, has shown strong results against COVID-19 infections in South Korea and China.
As Anthony Watts notes here there have been at least three studies demonstrating its efficacy against the Coronavirus.

Here is one, by James M Todaro and Gregory J Rigano:
According to the summary:
Recent guidelines from South Korea and China report that chloroquine is an effective antiviral therapeutic treatment against Coronavirus Disease 2019.  Use of chloroquine (tablets) is showing favorable outcomes in humans infected with Coronavirus including faster time to recovery and shorter hospital stay.  US CDC research shows that chloroquine also has strong potential as a prophylactic (preventative) measure against coronavirus in the lab, while we wait for a vaccine to be developed.  Chloroquine is an inexpensive, globally available drug that has been in widespread human use since 1945 against malaria, autoimmune and various other conditions.
It concludes:
Chloroquine can both prevent and treat malaria.  Chloroquine can both prevent and treat coronavirus in primate cells (Figure 1 and Figure 2).  According to South Korean and China human treatment guidelines, chloroquine is effective in treating COVID-19.  Given chloroquine’s human safety profile and existence, it can be implemented today in the U.S., Europe and the rest of the world.  Medical doctors may be reluctant to prescribe chloroquine to treat COVID-19 since it is not FDA approved for this use.  The United States of America and other countries should immediately authorize and indemnify medical doctors for prescribing chloroquine to treat COVID-19.  We must explore whether chloroquine can safely serve as a preventative measure prior to infection of COVID-19 to stop further spread of this highly contagious virus.
Here is the second study by Jianjun Gao, Zhenxue Tian, Xu Yang
Abstract:
The coronavirus disease 2019 (COVID-19) virus is spreading rapidly, and scientists are endeavoring to discover drugs for its efficacious treatment in China. Chloroquine phosphate, an old drug for treatment of malaria, is shown to have apparent efficacy and acceptable safety against COVID-19 associated pneumonia in multicenter clinical trials conducted in China. The drug is recommended to be included in the next version of the Guidelines for the Prevention, Diagnosis, and Treatment of Pneumonia Caused by COVID-19 issued by the National Health Commission of the People’s Republic of China for treatment of COVID-19 infection in larger populations in the future.

Here is the third, in the journal Nature
It’s titled ‘Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro’
Extract:
Chloroquine, a widely-used anti-malarial and autoimmune disease drug, has recently been reported as a potential broad-spectrum antiviral drug.8,9 Chloroquine is known to block virus infection by increasing endosomal pH required for virus/cell fusion, as well as interfering with the glycosylation of cellular receptors of SARS-CoV.10 Our time-of-addition assay demonstrated that chloroquine functioned at both entry, and at post-entry stages of the 2019-nCoV infection in Vero E6 cells (Fig. 1c, d). Besides its antiviral activity, chloroquine has an immune-modulating activity, which may synergistically enhance its antiviral effect in vivo. Chloroquine is widely distributed in the whole body, including lung, after oral administration. The EC90 value of chloroquine against the 2019-nCoV in Vero E6 cells was 6.90 μM, which can be clinically achievable as demonstrated in the plasma of rheumatoid arthritis patients who received 500 mg administration.11 Chloroquine is a cheap and a safe drug that has been used for more than 70 years and, therefore, it is potentially clinically applicable against the 2019-nCoV.

What does this mean?
Essentially it means the end of the nightmare is – or ought to be – much closer than we think.
It will take many, many months before a vaccine is available for COVID-19. In the meantime, this is a very effective stop-gap solution. Not only does it make those critically affected by the virus less likely to die; but it also acts as a prophylactic – that is, it is capable of stopping people from getting the disease in the first place.

The reason that Chloroquine works, I understand from an expert in viral pandemics, is that enables the body to absorb more zinc.
Zinc appears to be the most effective agent in disrupting the virus and preventing the ‘cytokine storm’, which is the deadly phase in which the virus tricks the body’s immune system into attacking its own healthy tissue, with often fatal consequences.


Cytokine release syndrome


Cytokine release syndrome
 (CRS) is a form of systemic inflammatory response syndrome that can be triggered by a variety of factors such as infections and certain drugs.[3] It occurs when large numbers of white blood cells are activated and release inflammatory cytokines, which in turn activate yet more white blood cells. CRS is also an adverse effect of some monoclonal antibody drugs, as well as adoptive T-cell therapies.[4][5] Severe cases have been called cytokine storms.[2] When occurring as a result of drug administration, it is also known as an infusion reaction.[1]

CRS is a form of systemic inflammatory response syndrome and is an adverse effect of some drugs.[4]


The first reference to the term cytokine storm in the published medical literature appears to be by Ferrara et al. in 1993 in a discussion of graft vs. host disease; a condition in which the role of excessive and self-perpetuating cytokine release had already been under discussion for many years.[14][15] The term next appeared in a discussion of pancreatitis in 2002, and in 2003 it was first used in reference to a reaction to an infection.[14]

It is believed that cytokine storms were responsible for the disproportionate number of healthy young adult deaths during the 1918 influenza pandemic, which killed 50 to 100 million people.[16] In this case, a healthy immune system may have been a liability rather than an asset. Preliminary research results from Taiwan also indicated this as the probable reason for many deaths during the SARS epidemic in 2003.[17] Human deaths from the bird flu H5N1 usually involve cytokine storms as well.[18] Cytokine storm has also been implicated in hantavirus pulmonary syndrome.[19]

In 2006, a medical study at Northwick Park Hospital in England resulted in all 6 of the volunteers given the drug TGN1412 becoming critically ill, with multiple organ failure, high fever, and a systemic inflammatory response.[20] Parexel, a company conducting trials for pharmaceutical companies, in one of its own documents, wrote about the trial and said TGN1412 could cause a cytokine storm—the dangerous reaction the men experienced.[21]

In the 2019–20 coronavirus pandemic, a number of deaths due to COVID-19 have been attributable to cytokine release storms.[22][23][24]


Why isn’t there more excitement about this readily available treatment?
One possible reason is that chloroquine is a generic drug to which no pharmaceutical company owns the patent. Big Pharma’s money and lobbying power will strive to persuade governments – and markets – that the only viable solution to the coronavirus is a vaccine. But in the short term this simply isn’t true. Nor is it clear to me that the global economy is going to survive on lockdown for as long as it takes to develop and test that vaccine – which may not even prove effective in any case.
Note that point in the Todaro and Rigano paper about the need for FDA approval. There is no time to waste.
Medical staff shows on February 26, 2020 at the IHU Mediterranee Infection Institute in Marseille, packets of a Nivaquine, tablets containing chloroquine and Plaqueril, tablets containing hydroxychloroquine, drugs that has shown signs of effectiveness against coronavirus. - The Mediterranee infection Institute in Marseille based in La Timone Hospital is at the forefront of the prevention against coronavirus in France. (Photo by GERARD JULIEN / AFP) (Photo by GERARD JULIEN/AFP via Getty Images)
Medical staff shows at the IHU Mediterranee Infection Institute in Marseille, packets of a Nivaquine, tablets containing chloroquine and Plaqueril, tablets containing hydroxychloroquine, drugs that has shown signs of effectiveness against coronavirus. 
– The Mediterranee infection Institute in Marseille based in La Timone Hospital is at the forefront of the prevention against coronavirus in France. ( GERARD JULIEN/AFP via Getty Images)
UPDATE: The Stanford University School of Medicine and National Academy of Sciences Researchers told the Huffington Post that they were not associated with the study conducted by James Todaro and Gregory Rigano. This story has been edited to reflect that.

HealthLondon / EuropePoliticsbig pharmaChloroquinecoronavirusCOVID-19Malaria

perjantai 20. maaliskuuta 2020

Coronavirus Is Biological Warfare Weapon

  • Security breach by Chinese nationals at the Canadian (P4) National Microbiology Lab in Winnipeg.
  • The Wuhan wet market incorrectly referred to as a seafood market, has been shown by experts to not be the source of the deadly contagion.




Dr. Francis Boyle Creator Of BioWeapons Act Says Coronavirus Is Biological Warfare Weapon
By GreatGameIndia | February 3, 2020

In an explosive interview Dr. Francis Boyle, who drafted the Biological Weapons Act has given a detailed statement admitting that the 2019 Wuhan Coronavirus is an offensive Biological Warfare Weapon and that the World Health Organization (WHO) already knows about it.


Dr. Francis Boyle Creator Of BioWeapons Act Says Coronavirus Is Biological Warfare Weapon

Francis Boyle is a professor of international law at the University of Illinois College of Law. He drafted the U.S. domestic implementing legislation for the Biological Weapons Convention, known as the Biological Weapons Anti-Terrorism Act of 1989, that was approved unanimously by both Houses of the U.S. Congress and signed into law by President George H.W. Bush.
In an exclusive interview given to Geopolitics and Empire, Dr. Boyle discusses the coronavirus outbreak in Wuhan, China and the Biosafety Level 4 laboratory (BSL-4) from which he believes the infectious disease escaped. He believes the virus is potentially lethal and an offensive biological warfare weapon or dual-use biowarfare weapons agent genetically modified with gain of function properties, which is why the Chinese government originally tried to cover it up and is now taking drastic measures to contain it. The Wuhan BSL-4 lab is also a specially designated World Health Organization (WHO) research lab and Dr. Boyle contends that the WHO knows full well what is occurring.
Dr. Boyle also touches upon GreatGameIndia‘s exclusive report Coronavirus Bioweapon – where we reported in detail how Chinese Biowarfare agents working at the Canadian lab in Winnipeg were involved in the smuggling of Coronavirus to Wuhan’s lab from where it is believed to have been leaked.
Watch Dr. Francis Boyle’s interview with Geopolitics and Empire below:
India in Cognitive Dissonance Book by GreatGameIndia

Coronavirus- Interview with Dr. Francis A. Boyle 

Dr. Boyle’s position is in stark contrast to the mainstream media’s narrative of the virus being originated from the seafood market, which is increasingly being questioned by many experts.
Recently, American Senator Tom Cotton of Arkansas also dismantled the mainstream media’s claim on Thursday that pinned the coronavirus outbreak on a market selling dead and live animals.
In a video accompanying his post, Cotton explained that the Wuhan wet market (which Cotton incorrectly referred to as a seafood market) has been shown by experts to not be the source of the deadly contagion.
Cotton referenced a Lancet study which showed that many of the first cases of the novel coronavirus, including patient zero, had no connection to the wet market — devastatingly undermining mainstream media’s claim.
“As one epidemiologist said: ‘That virus went into the seafood market before it came out of the seafood market.’ We still don’t know where it originated,” Cotton said.
“I would note that Wuhan also has China’s only bio-safety level four super laboratory that works with the world’s most deadly pathogens to include, yes, coronavirus.”

China claimed—for almost two months—that coronavirus had originated in a Wuhan seafood market. That is not the case. @TheLancet published a study demonstrating that of the original 40 cases, 14 of them had no contact with the seafood market, including Patient Zero.


Such concerns have also been raised by J.R. Nyquist, the well known author of the books “Origins of the Fourth World War” and “The Fool and His Enemy,” as well as co-author of “The New Tactics of Global War”. In his insightful article he published secret speechs given to high-level Communist Party cadres by Chinese Defense Minister Gen. Chi Haotian explaining a long-range plan for ensuring a Chinese national renaissance – the catalyst for which would be China’s secret plan to weaponiz viruses.
Nyquist gave three different data points for making his case in analyzing Coronavirus. He writes:
The third data point worth considering: the journal GreatGameIndia has published a piece titled “Coronavirus Bioweapon – How China Stole Coronavirus From Canada And Weaponized It.”


The authors were clever enough to put Khan’s Virology Journal article together with news of a security breach by Chinese nationals at the Canadian (P4) National Microbiology Lab in Winnipeg, where the novel coronavirus was allegedly stored with other lethal organisms. Last May, the Royal Canadian Mounted Police were called in to investigate; by late July the Chinese were kicked out of the facility. The chief Chinese scientist (Dr. Xiangguo Qiu) was allegedly making trips between Winnipeg and Wuhan.
Here we have a plausible theory of the NCoV organism’s travels: first discovered in Saudi Arabia, then studied in Canada from whence it was stolen by a Chinese scientist and brought to Wuhan. Like the statement of Taiwan’s intelligence chief in 2008, the GreatGameIndia story has come under intensive attack. Whatever the truth, the fact of proximity and the unlikelihood of mutation must figure into our calculations.


It’s highly probable that the 2019-nCoV organism is a weaponized version of the NCoV discovered by Saudi doctors in 2012.
Meanwhile, the mainstream media’s narrative still maintains that the origin of the 2019 Coronavirus is the Wuhan Seafood Market. After GreatGameIndia published the story on Coronavirus Bioweapon – not only were our databse tinkered with and our reports blocked by Facebook on the flimsy reason that they could not find GreatGameIndia Facebook page, but the report itself was viciously attacked by Foreign Policy magazine, PolitiFact (known widely as Facebook’s propaganda arm) and BuzzFeedNews.
It is not GreatGameIndia alone which is being viciously attacked. Zero Hedge, a popular alternate media blog was suspended by Twitter for publishing a story related to a study by Indian scientists finding 2019 Wuhan Coronavirus to be not naturally evolved, raising the possibility of it being created in a lab. Shockingly, the study itself came under intense online criticism by Social Media experts resulting in the scientists withdrawing the paper.
In retaliation India has launched a full-scale investigation against China’s Wuhan Institute of Virology. The Indian government has ordered an inquiry into a study conducted in the Northeastern state of Nagaland (close to China) by researchers from the U.S., China and India on bats and humans carrying antibodies to deadly viruses like Ebola.

The study came under the scanner as two of the 12 researchers belonged to the Wuhan Institute of Virology’s Department of Emerging Infectious Diseases, and it was funded by the United States Department of Defense’s Defense Threat Reduction Agency (DTRA).
The study, conducted by scientists of the Tata Institute of Fundamental Research, the National Centre for Biological Sciences (NCBS), the Wuhan Institute of Virology, the Uniformed Services University of the Health Sciences in the U.S. and the Duke-National University in Singapore, is now being investigated for how the scientists were allowed to access live samples of bats and bat hunters (humans) without due permissions.
The results of the study were published in October last year in the PLOS Neglected Tropical Diseases journal, originally established by the Bill and Melinda Gates Foundation.
As the author J.R. Nyquist puts it:
We must have an investigation of the outbreak in Wuhan. The Chinese must grant the world total transparency. The truth must come out. If Chinese officials are innocent, they have nothing to hide. If they are guilty, they will refuse to cooperate.
The real concern here is whether the rest of the world has the courage to demand a real and thorough investigation. We need to be fearless in this demand and not allow “economic interests” to play a coy and dishonest game of denial. We need an honest inquiry. We need it now.

GreatGameIndia Coronavirus Coverage

For latest updates on the outbreak check out our Coronavirus Coverage.
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